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One possibility is that it favours carriers by protecting them from disease. Plague fits the bill, he and his colleagues conclude from a mathematical modelling study published in the Journal of Medical Genetics 1. As the centuries wore on, repeated outbreaks, culminating in the Great Plague of London in the s, have occurred in tandem with rises in the mutation's frequency. Other experts are not convinced, however.

A similar study 2 published in suggests that it was smallpox that boosted the mutation's frequency.

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